Health Care Provider Resources

Genetics Privacy

• Oregon Genetics Privacy Opt-Out Factsheet (pdf)
  • Spanish version: Hoja Informativa Para Usuarios de Atención Médica, Privacidad Genética e Investigación (pdf)
• Oregon Genetics Privacy Opt-Out Sample notice (pdf)
  • Spanish version: EJEMPLO de Notificación, Declaración y Formulario de Opción de Exclusión (pdf)

National Human Genome Research Institute

• Genetics and Genomics for Health Professionals
  This website provides reliable, up-to-date genetics and genomics information related to patient management, curricular resources, new National Institutes of Health and NHGRI research activities, and ethical, legal and social issues.

Educational Materials

Making Sense of Cancer Headlines

FORCE's XRAYS program, funded by CDC, is a reliable resource for young breast cancer survivors and high-risk women to navigate through breast cancer research related news and information.

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Information about Genetic Conditions

• GeneReviews
  Database of detailed reviews on genetic diseases created through funding from the National Library of Medicine, NIH and National Human Genome Research Institute, NIH.
• Online Mendelian Inheritance in Man (OMIM)
  Database and catalog of human genes and genetic disorders.
• Society of Gynecologic Oncology - 2016 Genetics Toolkit
  This is a toolkit designed to provide critical, practical information to health care providers interested in gaining a deeper understanding of the role of genetics in gynecologic cancers.

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Pharmacogenomics

• Pharmacogenomics
  Contains news, background information, and education programs for pharmacists, including continuing education credits.  Materials were created by the School of Pharmacy at University of California, San Diego.

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Practice Guidelines

Evaluation of Genomic Applications in Practice and Prevention (EGAPP)
EGAPPS's goal is to establish and evaluate a systematic, evidence-based process for assessing genetic tests and other applications of genomic technology in transition from research to clinical and public health practice.

     Recommendations:

• Testing for Cytochrome P450 Polymorphisms (CYP450) in Adults with Non-Psychotic Depression Prior to Treatment with Selective Serotonin Reuptake Inhibitors (SSRIs). (PDF)
• Can UGT1A1 Genotyping Reduce Morbidity and Mortality in Patients with Metastatic Colorectal Cancer Treated with Irinotecan? (PDF)
• Can tumor gene expression profiling improve outcomes in patients with breast cancer? (PDF)
• Genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. (PDF)

     Evidence Reports:

• Outcomes of Genetic Testing in Adults with a History of Venous Thromboembolism
  The Johns Hopkins University Evidence Based Practice Center - June 2009
• Can UGT1A1 Genotyping Reduce Morbidity and Mortality in Patients with Metastatic Colorectal Cancer Treated with Irinotecan? (PDF)
  CDC, in conjunction with IPMMS and RTI | January 2009
• EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome. (PDF)
  CDC/OPHG in collaboration with IPMMS | January 2009
• Hereditary Nonpolyposis Colorectal Cancer: Diagnostic Strategies and Their Implications
  Tufts New England Medical Center Evidence Based Practice Center | May 2007
• Testing for Cytochrome P450 Polymorphisms (CYP450) in Adults with Non-Psychotic Depression Prior to Treatment with Selective Serotonin Reuptake Inhibitors (SSRIs)
  Duke University AHRQ Evidence-based Practice Center | January 2007
• Genomic Tests for Ovarian Cancer Detection and Management
  Duke University AHRQ Evidence-based Practice Center | October 2006
  

U.S. Preventive Services Task Force (USPSTF)
An independent panel of experts in primary care and prevention that systematically reviews the evidence of effectiveness and develops recommendations for clinical preventive services.

     Recommendations:

• Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility
• Screening for Colorectal Cancer
• Guide to Clinical Preventive Services, 2010 - 2011 (pocket guide)

     Evidence Reports:

• Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes
• Collection and Use of Cancer Family History in Primary Care?
• Enhancing Use and Quality of Colorectal Cancer Screening
• Family History and Improving Health
• Hereditary Nonpolyposis Colorectal Cancer: Diagnostic Strategies and Their Implications
• Genomic Tests for Ovarian Cancer Detection and Management

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Cancer Genetics

• National Comprehensive Cancer Network Genetic/Familial High-Risk Assessment Guidelines
  The National Comprehensive Cancer Network (NCCN) is an alliance of multiple cancer centers that are working together to develop guidelines for cancer risk assessment and treatment. NCCN offers familial risk assessment for breast and/or ovarian and colorectal cancer.  (Requires registration; anyone can register)
• Genetics of Breast and Ovarian Cancer Information for health professionals created by the National Cancer Institute, National Institutes of Health.
• Oregon Cancer Prevention and Control Program
  Cancer is a complex and often deadly disease that has no single cause or simple cure. As a state, we currently address cancer through a variety of approaches that include cancer prevention, early detection and survivorship. One part of this work is increasing the proportion of Oregonians who are aware of genetic factors that increase individual cancer risk.
• BRCA1 & BRCA2 Mutation Prevalence Table 
  Created by Myriad Genetic Laboratories, Inc.
• Familial Cancer Risk Assessment: Breast and Ovarian Cancer PowerPoint presentation, 2004
• Familial Cancer Risk Assessment: Colorectal Cancer PowerPoint presentation, 2004

See also: Public Resources (includes family history factsheets)

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Diabetes and Family History

• Family History and Diabetes
  PowerPoint review for public health professionals, 2004.
• Genetics for Targeted Disease Prevention: Diabetes
  Journal article abstract provides an overview of current thinking regarding genetics and diabetes (type 1, type 2, and gestational diabetes mellitus), including a selective look at a few implicated variants, 2004.
• State of Oregon Diabetes Program
  The State of Oregon Diabetes Program's goal is to reduce the burden of diabetes in Oregon through a public health approach, working in collaboration with partners in the public and private sectors.

See also: Public Resources (includes Diabetes and family history factsheets)

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Preconception/Prenatal Genetic Screening

Materials were created through funding from the March of Dimes Oregon Chapter in 2004-2005.

• Prenatal Genetic Screening
  PowerPoint presentation
• Ethnicity-Based Genetic Carrier Screening
  PowerPoint presentation
• Maternal Serum Screening
  PowerPoint Presentation
• Preconception/Prenatal Family History Questionnaire 
  March of Dimes
• Preconception/Prenatal Family History Assessment/Management Guide 
  March of Dimes

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Collecting and Using Family History

• All in the Family
  A resource (CD-Summary) for providers on ways of using family history to identify and prevent disease in high-risk populations.
• Sample Family Health History Form for Federally-Qualified Health Center
  Although originally created for Federally-Qualified Health Center (FQHC) providers in Oregon, this clinical template can be used to collect family history information from patients by any health care provider.

See also: Family Health History