PrEP & PEP

Clinical Guidelines and Other Resources for Service Providers

Take emergency PEP after an HIV exposure

PEP (post-exposure prophylaxis) is an emergency medicine that prevents HIV after an exposure. PEP must be started as soon as possible – ideally within 24 hours, and no later than 72 hours (3 days) after exposure. PEP is an oral medication (pills) taken every day for 28 days. PEP is safe and very effective when started right away and taken correctly.

How do I get PEP?

Talk to your healthcare provider, an emergency room doctor, or an urgent care provider immediately if you think you've been exposed to HIV.
All Oregon hospitals are required to provide PEP to those who need it.
Most health insurance plans, including the Oregon Health Plan, cover PEP medications and related healthcare visits. There are assistance programs to help you pay for PEP if you do not have insurance.
Not all pharmacies currently stock PEP medications. This online directory lists pharmacies that stock medications commonly prescribed for PEP.

Have more questions about PEP or need help accessing PEP?

Check out our HIV Post-Exposure Prophylaxis (PEP) Resources for Patients (English & Spanish)
Contact a navigator for free assistance.

Plan ahead: prevent HIV with PrEP

PrEP (pre-exposure prophylaxis) is medicine for adults and adolescents without HIV who want to reduce their chance of getting HIV from sex or injection drug use. PrEP is available as an oral medication (pills) and as an injectable medication (shots given by a healthcare provider). When taken correctly, PrEP can reduce the risk of getting HIV through sex by more than 99% and can reduce the risk of getting HIV among people who inject drugs by up to 74%.

How do I get PrEP?

Talk to your healthcare provider if you're interested in starting PrEP, or find a provider on the PrEP Provider List.
Most health insurance plans, including the Oregon Health Plan, cover PrEP medications and related healthcare visits. There are assistance programs to help you pay for PrEP if you do not have insurance.

Have more questions about PrEP or need help accessing PrEP?

Check out our PrEP Access FAQs (English & Spanish)
Contact a navigator for free assistance.

Navigation

Do you need help to access PEP or PrEP? Navigators are available across the state to help you find, pay for, and use PEP and PrEP. Navigation is a free service. Contact the organization that serves your area:

Portland metropolitan area: Cascade AIDS Project
Southwestern Oregon/Oregon coast: HIV Alliance
Eastern Oregon: Eastern Oregon Center for Independent Living

For Providers

Clinical Guidelines

PEP:

The need for PEP is a medical emergency. PEP is ideally started within 24 hours of exposure but may be started within 72 hours of exposure.
2025 nPEP Guidelines: Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV — CDC Recommendations, United States, 2025 (pdf)
2025 oPEP Guidelines: 2025 US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Post-exposure Prophylaxis in Healthcare Settings (pdf)

PrEP:

2021 PrEP Guidelines Supplement: Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2021 Update: Clinical Providers' Supplement (pdf)
2021 PrEP Guidelines: Preexposure prophylaxis for the prevention of HIV infection in the United States – 2021 Update: A Clinical Practice Guideline (pdf)
2025 Injectable Lenacapavir as PrEP Guidelines: Clinical Recommendation for the Use of Injectable Lenacapavir as HIV Preexposure Prophylaxis — United States, 2025 (pdf)

Current guidelines and recommendations are also listed on CDC’s HIV Nexus page.

Other Resources:

PrEP Guide for Providers and Navigators, October 2024 (pdf)
PrEP Access FAQ Patient Handout, October 2024 (pdf): English, Spanish
Guidance for Hospitals: Dispensing of 5-day Supply of HIV PEP, January 2024 (pdf)
List of PrEP/PEP Prescribing Trainings for Oregon Pharmacists (pdf)
Overview of Pharmacist Prescribed PrEP and PEP in Oregon (pdf)
Oregon Medicaid Pharmacy Quick Reference, December 2020 (pdf)
Contact the National Clinician Consultation Center (NCCC) at 844-ASK-NCCC for no-cost teleconsultation on PrEP, PEP, HIV/AIDS management, and more.
National HIV Curriculum (includes PEP) and National PrEP Curriculum

Want to be added to the PrEP Provider List?

Contact Oregon AETC if you are a prescribing clinician in Oregon or Washington and wish to be added to the Oregon AIDS Education and Training Center’s PrEP Provider List.