You won’t find the advice to avoid “regrettable substitutions” in a fortune cookie but just replacing a toxic chemicals without having better alternatives could mean moving backwards. That’s not acceptable. Nor is it necessary, given our modern technology and ingenuity.
After you've identified chemicals of concern by screening data or using an existing chemical hazard assessment, you can conduct an alternatives assessment. An alternatives assessment finds and compares possible chemical and non-chemical alternatives that are less likely to harm human health or the environment. This prevents the use of a “regrettable substitution.”